IMPORTANT SAFETY INFORMATION
What is UPNEEQ?
UPNEEQ ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.
What warnings and precautions are associated with UPNEEQ?
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Low-lying lids may be related to conditions such as
stroke and/or brain aneurysm, Horner syndrome, myasthenia
gravis, loss of the ability to move eye muscles, eye
infection and eye tumors. Tell your doctor if you have any
of these conditions.
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UPNEEQ is a type of medication that may affect your blood
pressure. If you have heart disease, uncontrolled high or
low blood pressure, or feel faint at rest or when quickly
standing up, you should call your doctor if your symptoms
get worse.
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Patients with reduced blood flow to the brain or heart,
or patients who experience eye or mouth dryness due to an
immune system disorder (Sjögren’s syndrome), should use
care when taking UPNEEQ. Call your doctor immediately if
you feel your symptoms may be getting worse.
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UPNEEQ may increase the risk of eye pressure due to fluid
buildup (angle-closure glaucoma) in patients with
untreated narrow-angle glaucoma. Call your doctor
immediately if you feel increased pressure in your eye
after using UPNEEQ.
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Do not let the tip of the UPNEEQ vial touch your eye or
any other surface. This can help prevent eye injury or
contamination. Each UPNEEQ vial is for one-time use and
should be discarded after being used.
What are the most common side effects of UPNEEQ?
The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.
What should my doctor know about before prescribing me UPNEEQ?
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Your doctor should review your full medical history
before prescribing UPNEEQ.
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UPNEEQ belongs to a class of medication (alpha-adrenergic
agonists) that may affect your blood pressure. Use UPNEEQ
carefully if you currently take an alpha-adrenergic
agonist medication to treat heart disease or an enlarged
prostate. Patients taking beta-blockers, or other
medications to treat hypertension or an abnormal
heartbeat, should also be careful when using UPNEEQ.
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Patients who use a certain class of antidepressant
medication (monoamine oxidase inhibitors) should also be
careful when using UPNEEQ, as it may affect the way your
body absorbs the medication.
These are not all of the possible side effects of UPNEEQ. Tell
your doctor if you have any side effect that bothers you or
does not go away. Call your doctor for medical advice about
side effects.
To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit www.fda.gov/medwatch.
This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.